News:

Here we provide you with news articles, blogs and tweets on the key aspects of our bioinformatics and drug resistance work.

In this new section of the bioafrica.net website, we disseminate printed and online media coverage of our work and its application in everyday life.


News Latest News

KRISP Papers


Science Editorial: Inhibiting natural killer cells in AIDS

KRISP Papers - 2018-01-04

The human leukocyte antigen (HLA) gene complex varies enormously among individuals and helps explain individual variation in immunity to infectious diseases. Ramsuran et al. (Science 2018) examined data from almost 10,000 HIV infections.

Expression of the HLA-A and -B alleles was associated with higher viral load, reduced CD4+ T cell counts, and accelerated progression to AIDS. Higher levels of HLA-A expression increased expression of HLA-E, which blocks a specific receptor (NKG2A) on the immune cells that normally eliminate virus-infected cells. Thus, targeting NKG2A might provide a therapeutic avenue for HIV treatment. Read Ramsuran et al. 2018 (Open access).

Links:

http://science.sciencemag.org/content/359/6371/86.editor-summary

Publication cited

Elevated HLA-A expression impairs HIV control through inhibition of NKG2A-expressing cells. Ramsuran V, Vivek Naranbhai, Amir Horowitz, Ying Qi, Maureen P. Martin, Yuko Yuki, Xiaojiang Gao, Victoria Walker-Sperling, Gregory Q. Del Prete, Douglas K. Schneider, Jeffrey D. Lifson, Jacques Fellay, Steven G. Deeks, Jeffrey N. Martin, James J. Goedert, Steven M. Wolinsky, Nelson L. Michael, Gregory D. Kirk, Susan Buchbinder, David Haas, Thumbi Ndung'u, Philip Goulder, Peter Parham, Bruce D. Walker, Jonathan M. Carlson and Mary Carrington, Science (2018), 359:86-90.

15 minutes, All news...

Science Editorial: Inhibiting natural killer cells in AIDS
From KRISP Papers, date: 2018-01-04

Why KRISP? KRISP challenges the status quo to create a scientific environment in South Africa that drives innovations & reverses the brain drain.
From Why KRISP?, date: 2017-12-31

Science TM Editorial: Status is not everything
From KRISP Papers, date: 2017-12-15
15 minutes, All news...


Page design updated by Tulio de Oliveira, 2015