Encapsulates and protects viral dimeric unspliced (genomic) RNA
Nucleic acid condensing and chaperoning protein that binds to the virion genomic
RNA (gRNA) and facilitates structural rearrangements of the genomic RNA in the course
of replication by the viral reverse transcriptase.
Enhances various steps in reverse transcription including tRNA annealing and
Also plays a role in template switch, leading to recombination
As part of the Gag polyprotein, NC participates
in gRNA dimerization, packaging, tRNA incorporation and virion assembly.
May also contribute to the initial binding of the bent form of Gag
to the plasma membrane
Host nucleus (covers DNA flaps)
Late timing of expression.
The HIV packaging signal consists of 4 stem-loop structures near the 5'-end of viral RNA.
The HIV packaging signal is sufficient to mediate the incorporation of heterologous RNA into virions
Gag-NC Function & Host-Virus Protein Interactions:[TOP]
NC contains two zinc-finger motifs, which recognize the
dimerization (DIS) and packaging (Psi) sequences, and interact with the 4 stem-loop structures of the HIV packaging signal. This allows for the
dimerization and packaging of the genomic RNA
Int J Biochem Cell Biol. 36(9):1776-86 (2004) [pubmed: 15183344]
12 - Formation of immature and mature genomic RNA dimers in wild-type and protease-inactive HIV-1: differential roles of the Gag polyprotein, nucleocapsid proteins NCp15, NCp9, NCp7, and the dimerization initiation site.
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