HIV proteome (Lifecycle)

The HIV-1 subtype C lifecycle is a complex multistage process involving interactions between HIV-1 proteins and host macromolecules. The Early phase of the lifecycle consists of infection of host cell and integration of viral genome, and the Late phase of the lifecycle consists of regulated expression of the viral gene products, and production of viral particles. You can find out information about each of the HIV-1 proteins, by clicking on the protein within the diagram.



Capsid NucleoCapsid gp120 gp41 Vif Reverse Transcriptase Matrix Vpr Integrase Tat Rev Nef Vpu Protease Viral Attachment Fusion Capsid Release Nuclear import of pre-integration complexes Host DNA Nuclear export of spliced mRNA to cytoplasm Ribosome Translation Immature Virus Budding Mature Virus
Structural Proteins:

* Gag polyprotein
 - p17 Matrix
 - p24 Capsid
 - p2
 - p7 Nucleocapsid
 - p1
 - p6 Vpr binding

* Env polyprotein
 - gp120 Surface
 - gp41 Transmembrane
Enzymatic Proteins:

* Pol polyprotein
 - p51 Reverse Transciptase
 - p15 RNase H
 - p66 RT+RNase H
 - p10 Protease
 - p31 Integrase
Accessory Proteins:

* Nef protein (p27/p25)
* Vif protein (p23)
* Vpr protein (p12/p10)
* Vpu protein (p16)
Regulatory Proteins:

* Rev protein (p19)
* Tat protein (p16/p14)


Page last updated by Tulio de Oliveira.