HIV lifecycle is a complex multistage process involving
interactions between HIV proteins and host macromolecules. The Early
phase of the lifecycle consists of infection of host cell
and integration of viral genome, and the Late phase of
the lifecycle consists of regulated expression of the viral gene
products, and production of viral particles. You can find
out information about each of the HIV-1 proteins, by clicking on the
protein within the table.
To help users to access virus and host genomic data in a useful way, we have created an HIV resource that organizes knowledge and aims to give a broad view of the HIV life cycle and its interaction with human proteins. This resource has been created following an extensive review of the literature. The lifecycle is annotated with controlled vocabulary linked to dedicated pages in ViralZone, Gene Ontology, and UniProt resources. The HIV proteins in the cycle are linked to ViralZone annotation pages, UniProt HIV entries and this resource, the BioAfrica HIV proteome resource.