HIV proteome (Lifecycle)

The HIV lifecycle is a complex multistage process involving interactions between HIV proteins and host macromolecules. The Early phase of the lifecycle consists of infection of host cell and integration of viral genome, and the Late phase of the lifecycle consists of regulated expression of the viral gene products, and production of viral particles. You can find out information about each of the HIV-1 proteins, by clicking on the protein within the table.

To help users to access virus and host genomic data in a useful way, we have created an HIV resource that organizes knowledge and aims to give a broad view of the HIV life cycle and its interaction with human proteins. This resource has been created following an extensive review of the literature. The lifecycle is annotated with controlled vocabulary linked to dedicated pages in ViralZone, Gene Ontology, and UniProt resources. The HIV proteins in the cycle are linked to ViralZone annotation pages, UniProt HIV entries and this resource, the BioAfrica HIV proteome resource.

Click in a HIV-1 protein in the replication cycle or select it from the list:


HIV Life Cycle, protein functions

Capsid NucleoCapsid gp41 Vif Reverse Transcriptase RNAse Matrix Vpr Integrase Tat Rev Nef Vpu Protease P6 Vpr Vpr Vpr

Color code for proteins across the images presented in the proteome resource:





Thanks to ViralZone at the Swiss Institute of Bioinformatics (SIB) for allowing the use of their images on bioafrica.net.
Page last updated by Megan Druce, Paula Sommer and Tulio de Oliveira (UKZN/Africa Centre) & Philippe Le Mercier, Chantal Hulo and Patrick Masson (SIB/ViralZone).