Title: A qualitative and quantitative histopathological analysis of the host immune response to TB of the spine in HIV-positive and negative patients
Authors: Danaviah S, Sacks J, Taylor L, Govender S, Fallows D, Kumar KPS, Ndung'u T, Kaplan G. .
Journal: Tuberculosis,93(4):432-41 (2013)
Journal Impact Factor (I.F.): 3.036
Tuberculosis (TB) is mainly a disease of the lungs, but Mycobacterium tuberculosis (Mtb) can establish
infection in virtually any organ in the body. Rising rates of extrapulmonary (EP) TB have been largely
associated with the HIV epidemic, as patients co-infected with HIV show a four-fold higher risk of EPTB.
Spinal TB (Pott?s Disease), one of the most debilitating extrapulmonary forms of disease, is difficult to
diagnose and can cause deformity and/or neurological deficits.
This study examined the histopathology
and distribution of immune cells within spinal TB lesions and the impact of HIV on pathogenesis.
The overall structure of the spinal granulomas resembled that seen in lung lesions from patients with
pulmonary TB. Evidence of efficient macrophage activation and differentiation were detectable within
organized structures in the spinal tissue, irrespective of HIV status. Interestingly, the granulomatous
architecture and macroscopic features were similar in all samples examined, despite a reversal in the
ratio of infiltrating CD4 to CD8 T cells in the lesions from HIV-infected patients.
This study provides a
foundation to understand the mechanism of tissue destruction and disease progression in Spinal TB,
enabling the future development of novel therapeutic strategies and diagnostic approaches for this
Citation: Danaviah S, Sacks J, Taylor L, Govender S, Fallows D, Kumar KPS, Ndung'u T, Kaplan G. . A qualitative and quantitative histopathological analysis of the host immune response to TB of the spine in HIV-positive and negative patients Tuberculosis,93(4):432-41 (2013).