Southern African Treatment and Resistance Network (SATuRN)

SATuRN currently includes 24 research partners in southern Africa that support our initiatives. We have collated over 7,000 resistance genotypes linked to treatment and clinical information and host two of the best HIV drug resistance databases in the world (The Stanford HIV Drug Resistance Database and RegaDB Clinical Management and Drug resistance Database). To advance access to drug resistance testing to patients, providers and programs, we have been working with a network of academics laboratories to develop and implement a cheaper resistance genotype test. We have also delivered training in drug resistance testing and management to over 2,000 physician and nurses in southern Africa...

SATuRN Newsletters:

SATuRN newsletters:

Num 1 V.5 (Jan-Mar 2016)


SATuRN Mission/Vision

SATuRN Executive Summary

Who We Are: SATuRN Management, Participant Scientists, International Advisory Board, Funders

Information for Collaborators:

Manual of Operations (MoO) - reference to SATuRN organization, functions and access of data

Memorandum of Understanding (MoU) - deposit of data in SATuRN drug resistance databases (MSWord format)

Contributors Guidelines - website, newsletters and annual reports

Public Resources: HIV & TB Book and Online Databases

HIV & TB Drug Resistance and Clinical Management Casebook - Open access

SATuRN Stanford HIV Drug Resistance Database (HIVDB) -  Public Drug Resistance Databases in Southern Africa (de Oliveira et al. Nature 2010, 464:673)

SATuRN RegaDB Clinical Management Database - A Collaborative Clinical HIV Drug Resistance Database in Southern Africa

Open access pdf Publications (latest 5)

Elevated HLA-A expression impairs HIV control through inhibition of NKG2A-expressing cells.
Ramsuran V, Vivek Naranbhai, Amir Horowitz, Ying Qi, Maureen P. Martin, Yuko Yuki, Xiaojiang Gao, Victoria Walker-Sperling, Gregory Q. Del Prete, Douglas K. Schneider, Jeffrey D. Lifson, Jacques Fellay, Steven G. Deeks, Jeffrey N. Martin, James J. Goedert, Steven M. Wolinsky, Nelson L. Michael, Gregory D. Kirk, Susan Buchbinder, David Haas, Thumbi Ndung'u, Philip Goulder, Peter Parham, Bruce D. Walker, Jonathan M. Carlson and Mary Carrington, Science (2018), 359:86-90.

Green environment and incident depression in South Africa: a geospatial analysis and mental health implications in a resource-limited setting.
Tomita A, Vandormael AM, Cuadros D, Di Minin E, Heikinheimo V, Tanser F, Slotow R, Burns JK, Lancet Planetary Health (2017), 1:152?62.

Effect of population viral load on prospective HIV incidence in a hyperendemic rural African community.
Tanser F, Vandormael A, Cuadros D, Phillips AN, de Oliveira T, Tomita A, Barnighausen T, Pillay D, Science Translational Medicine (2017), 9:eaam8012.

Highlights of the second ISCB Student Council Symposium in Africa, 2017.
Rafael CN, Ashano E, Moosa Y, Shome S, DeBlasio D, F1000 Research (2017), 6(ISCB Comm J):2183 (doi: 10.12688/f1000research.13463.1).

HIV-1 drug resistance before initiation or re-initiation of first-line antiretroviral therapy in low-income and middle-income countries: a systematic review and meta-regression analysis.
Ravindra K Gupta, John Gregson, Neil Parkin, Hiwot Haile-Selassie, Amilcar Tanuri, Liliana Andrade Forero, Pontiano Kaleebu, Christine Watera, Avelin Aghokeng, Nicholus Mutenda, Janet Dzangare, San Hone, Zaw Zaw Hang, Judith Garcia, Zully Garcia, Paola Marchorro, Enrique Beteta, Amalia Giron, Raph Hamers, Seth Inzaule, Lisa M Frenkel, Michael H Chung, de Oliveira T, Deenan Pillay, Kogie Naidoo, Ayesha Kharsany, Ruthiran Kugathasan, Teresa Cutino, Gillian Hunt, Santiago Avila Rios, Meg Doherty, Michael R Jordan, Silvia Bertagnolio, Lancet Infectious Diseases (2017), :

All publications - Bioinformatics, genomics and drug resistance peer-reviewed papers on HIV, TB and other pathogens
News News Section, printed & online media on HIV & TB drug resistance and bioinformatics (latest 5)

KRISP Newsletter

KRISP Newsletter - Jan 2018: news, innovations, publications and training events

KRISP Newsletter - 2018-02-01

The concept behind this newsletter is that anyone with 15 minutes to spare can learn about the work of the KwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), which is a Platform of the Technology Innovation Agency (TIA) at University of KwaZulu-Natal (UKZN), Durban, South Africa. In the first edition of 2018, we bring you the Durban Spark Innovation Breakfast, news coverage of our Science paper and info about training events.


Effect of DNA methylation on HIV disease

KRISP Talks - 2018-01-26

KRISP Talks by Dr. Veron Ramsuran, KRISP, UKZN & CAPRISA, 26 January 2018 (15:00 - 16:00), K-RITH building, Nelson R Mandela School of Medicine, UKZN, Durban, South Africa. All welcome!


Our Paper on Green Environment & Depression Selected as One of the 20 Most Influential Conservation Ecology Papers of 2017 by F1000!

KRISP News - 2018-01-24

F1000 has produced another retrospective list of the top 20 influential conservation papers of 2017 as assessed by experts in the field. The manuscript by Tomita, Vandormael et al. Lancet Planetary Health 2017 on green environment and depression made this influencial list...


Science Discovery: Biomarkers for HIV treatment

KRISP News - 2018-01-19

Mercury Reporter, Durban, KwaZulu-Natal, 19 Jan 2018: Scientists led an in ternational research team which discovered new genetic markers that identify why the onset of Aids appears to occur so quickly in some people after they are infected with HIV The study published in the journal Science (Ramsuran et al. Science 2018), sheds new light on how specific human genes can lead to a faster deterioration for people living with HIV who are not on treatment.


SA study reveals important link between genes and Aids

KRISP News - 2018-01-19

HIV/AIDS researchers have never understood why people infected with HIV developed Aids at different times? but now they suspect that it all has to do with their genes. A study by South African and US researchers (Ramsuran et al. Science 2018) has shed new light on how specific genes in people can lead to the faster progression of Aids-related illnesses in people living with HIV who are not on treatment.

All news...
Blogs on bioinformatics, HIV & TB drug resistance, treatment, community engagement and bioinformatics in Africa Twitter

Bioinformaticians are pioneering the future of science

Author: Yumna Moosa - 2017-07-28

Meeting of the Swiss, Swedes and South Africans minds

Author: Nicolette Crozier, Benjamin Chimukangara, Veron Ramsuran - 2017-07-25

Megan Druce: from Cum Laude MSc to a Scholarship for a PhD in Germany...

Author: Megan Druce - 2016-04-18

Sthembiso Msweli: from Hlabisa to MSc and Further Promoted to Laboratory Manager...

Author: Sthembiso Msweli - 2016-04-17

Experience of 3 UKZN/Africa Centre students at the 7-week national bioinformatics workshop 2015

Author: Megan Druce, Zandile Sibisi & Sthembiso Msweli - 2015-04-23

15 minutes, All blogs...

Open access reports on HIV & TB drug resistance and bioinformatics in Africa HIV & TB Drug Resistance Clinical Cases Tutorial

SATuRN Collaborates on a Successful Molecular Diagnostics in HIV/AIDS and Tuberculosis in Zimbabwe, 6-9 Aug 2013

SATuRN 2013 report, date: 2013-08-21

Justen Manasa

SATuRN and Khethimpilo HIV Drug Resistance and Clinical Management Workshop Report, Durban, 11-12 July 2013

SATuRN 2013 report, date: 2013-08-01

Dean Solomon and Tulio de Oliveira

Major data analysis determines the trends of HIV-1 drug resistance mutations in South Africa.

SATuRN report 2013, date: 2013-07-01

Tulio de Oliveira

Transferring knowledge and skills to frontline medical personnel fighting the HIV & TB epidemics in rural South Africa

SATuRN 2013 report, date: 2013-03-16

Tulio de Oliveira, Justen Manasa, Richard Lessells & SATuRN webpages received 186,746 visits in the past 12 months!

SATuRN 2013 report, date: 2013-02-26

Tulio de Oliveira

Clinical Case Study: The Diagnosis and Management of First-line Antiretroviral Treatment Failure

SATuRN 2012 report, date: 2013-01-16

Theresa Rossouw, Tulio de Oliveira & Richard Lessells

2nd Nurses and Health Care Workers Drug Resistance Training for the scale-up of resistance testing in the Free State Province, South Africa

SATuRN 2012 report, date: 2012-07-10

Dominique Goedhals & Cloete van Vuuren

SATuRN output, 15 minutes, All reports...

SATuRN output, 15 minutes, All cases...

Page design updated by Prof. Tulio de Oliveira, 2011