Introduction: SATuRN - Southern African Treatment and Resistance Network and the Stanford HIV Drug Resistance Database

Over the past 5 years, there has been progress made in support of Southern African HIV ART programmes, namely the formation of a regional network for research on HIV drug resistance. As part of this network, named the Southern African Treatment and Resistance Network (SATuRN), we have recently installed a full Southern African mirror of the Stanford HIV Drug Resistance database (HIVDB) and a clinical management database based on RegaDB. In addition to bioinformatics programs and databases we have organized a number of national meetings with collaborators and medical personal involved on ART treatment at private and public sector.


Database link:
Mirror Stanford HIV Drug Resistance Database:




Southern African Mirror of the Stanford HIV Drug Resistance Database (HIVDB) A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance. 

Features:

HIVdb - Program Genotypic Resistance Interpretation Algorithm


Mutation Prevalence According to Subtype and Treatment

Studies by author stored in the HIV Drug Resistance Database

Protease Treatment Profile

Reverse Transcriptase Treatment Profile

Database Statistics


The mirror was installed by Soo-Yon Rhee, Tommy Liu, Tulio de Oliveira and Robert Shafer.

Letter:
SATuRN collaborators who co-signed the correspondence:











Signees of the correspondence in Nature:

(
Founding members of SATuRN and signees:)

Prof. David Katzenstein*, Stanford University, USA.

Prof. Lynn Morris*, National Institute of Communicable Diseases, Johannesburg, South Africa.

Prof. Rami Kantor, Brown University, USA.

Prof. Chris Seebregts*, Medical Research Council, Cape Town, South Africa.

Ziad El-Khatib, Division of Global Health, Karolinska Institutet, Sweden

(SATuRN collaborators and signees:)

Dr. Tulio de Oliveira*, Justen Manasa, Richard Lessells* and Prof. Marie-Louise Newell, from the Africa Centre for Health and Population Studies, University of KwaZulu-Natal, Somkhele, South Africa.

Prof. Sharon Cassol* and Dr. Theresa Rossouw, University of Pretoria, South Africa.

Prof. Lynne M. Webber, Head of Department of Medical Virology, University of Pretoria, South Africa.

Soo-Yon Rhee*,  Tommy Liu and Prof. Robert Shafer*,  Stanford University, USA.

Dr. Cloete van Vuuren, Dr. Dominique Goedhals, Dr. Dewald Steyn, Medical School, University of the Free State, South Africa.

Dr. Gert van Zyl, Prof. Susan Engelbretch, Prof. Wolfgang Preiser, Division of Medical Virology, Department Pathology, NHLS, Tygerberg and Stellenbosch University, South Africa.

Dr. Ashraf Grimwood, CEO, Kheth’Impilo, South Africa.

Dr. Ricardo Jorge Gonçalves Ornelas Camacho, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Portugal.

Prof. Christina Zarowsky, Prof. Debra J Jackson, School of Public Health, University of the Western Cape, South Africa.

Dr. Carole Wallis* and Prof. Wendy S. Stevens, Department of Molecular Medicine and Haematology, University of the Witwatersrand and the National health Laboratory Service, South Africa.

Dr. Gillian Hurt, National Institute of Communicable Diseases, Johannesburg, South Africa.

Prof. Anne-Mieke Vandamme, Laboratory for Clinical and Epidemiological Virology, AIDS Reference Laboratory, Rega Institute, Katholieke Universiteit Leuven, Belgium.

Dr. Diana Dickinson, private clinician, Gaborone, Botswana.

Prof. Robin Wood, Prof. Catherine Orrell, Desmond Tutu HIV Centre, University of Cape Town, South Africa.

Prof. Christopher Hoffmann, Aurum Institute for Health Research, Johannesburg, South Africa.

Prof. Thumbi Ndung'u and Dr. Michelle Gordon, HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal, South Africa.

* Individuals who participate in the writting process of the correspondence.


Nature HIV/AIDS outlook: Correspondence is now freely available and is featured in Nature special HIV/AIDS outlook publication!

Click on the picture to download editorial

 


  Nature special HIV/AIDS outlook supplementary publication:

  " This Nature HIV/AIDS Outlook publication shows that there is a renaissance afoot in the field. There is, for instance, hushed talk of something most people had given up on: a cure for HIV/AIDS. With more powerful new drugs and a clearer understanding of the virus’ ways, some researchers are quietly exploring approaches to flush the virus out of the body completely.

  Outside the laboratory, too, there is new hope. Experts are combining every tool at hand — such as mobile telephones, male circumcision and microbicides laced with antiretroviral drugs — to prevent new infections. Even South Africa, that hotbed of AIDS denialism, is finally facing up to its epidemic." Nature HIV/AIDS outlook editorial.

  As part of this special HIV/AIDS publication our correspondence on a public and HIV Drug Resistance Database in southern Africa was made freely available at Nature website. For those who went to the XVIII International AIDS Conference in Vienna, 2010, this Nature publication was  distributed free of charge, we hope you got yours as it contains excellent reviews (freely accessible) on cutting edge developments of the HIV/AIDS prevention, treatment and vaccine fields.





Links to web-resources and viral databases:


Comprehensive links to HIV treatment, ARVs and drug resistance at HIVDB.

Comprehensive information on antiretroviral therapy in South Africa at the Treatment Action Campaign (TAC) website.

5th South African HIV Drug Resistance and Treatment Monitoring Workshop at the University of the Free State Medical School, Bloemfontein, South Africa. 27 to 29 October 2010.

Stanford HIV Drug Resistance Database



SATuRN RegaDB:

RegaDB collaborative mode* This copy of the database is accessible to SATuRN collaborators. RegaDB is a clinical management bioinformatics database that can be used to manage patients on ARVs and to do research on HIV-1 drug resistance clinical cases. Only published results are stored in the database. *no personal identification data can be stored in this database.

Other Viral databases:

RNA Virus Database - An international collaboration to create a relational database to all RNA virus genomes.

ViralZone - ViralZone is a Swiss Institute of Bioinformatics web-resource for all viral genus and families, providing general molecular and epidemiological information, along with virion and genome figures.

NCBI Viral Genomes - GenBank entry point for viruses.

Los Alamos HIV Sequence Database - HIV sequence database with reviews and bioinformatics programs.

Southern African Treatment and Resistance Network (SATuRN) website.





Page last updated by Tulio de Oliveira.