Introduction: Southern African Treatment and Resistance Network (SATuRN)

SATuRN currently includes 24 research partners in southern Africa that support our initiatives. We have collated over 7,000 resistance genotypes linked to treatment and clinical information and host two of the best HIV drug resistance databases in the world (The Stanford HIV Drug Resistance Database and RegaDB Clinical Management and Drug resistance Database). To advance access to drug resistance testing to patients, providers and programs, we have been working with a network of academics laboratories to develop and implement a cheaper resistance genotype test. We have also delivered training in drug resistance testing and management to over 2,000 physician and nurses in southern Africa...

SATuRN Newsletters:
Information:

SATuRN newsletters:

Num 2 V.3 (Apr-Jul 2014)

Num 1 V.3 (Jan-Mar 2014)

Num 4 V.2 (Oct-Dec 2013)

Num 3 V.2 (Jul-Sep 2013)


Introduction:

SATuRN Mission/Vision

SATuRN Executive Summary

Who We Are: SATuRN Management, Participant Scientists, International Advisory Board, Funders


Information for Collaborators:

Manual of Operations (MoO) - reference to SATuRN organization, functions and access of data

Memorandum of Understanding (MoU) - deposit of data in SATuRN drug resistance databases (MSWord format)

Contributors Guidelines - website, newsletters and annual reports


Public Resources: HIV & TB Book and Online Databases

HIV & TB Drug Resistance and Clinical Management Casebook - Open access

SATuRN Stanford HIV Drug Resistance Database (HIVDB) -  Public Drug Resistance Databases in Southern Africa (de Oliveira et al. Nature 2010, 464:673)

SATuRN RegaDB Clinical Management Database - A Collaborative Clinical HIV Drug Resistance Database in Southern Africa


Training and Capacity Building Workshops

AIDS Workshop on Advanced Clinical Care and SATuRN 9th HIV & TB Drug Resistance Workshop, Elangeni Sun Hotel, Durban South Africa, 9th to 10th October 2014.

19th International Bioinformatics Workshop on Virus Evolution and Molecular Epidemiology, National Institute for Infectious Diseases L Spallanzani, Rome, Italy, September 7-12, 2014



Open access pdf Publications (latest 5)

Elevated HLA-A expression impairs HIV control through inhibition of NKG2A-expressing cells.
Ramsuran V, Vivek Naranbhai, Amir Horowitz, Ying Qi, Maureen P. Martin, Yuko Yuki, Xiaojiang Gao, Victoria Walker-Sperling, Gregory Q. Del Prete, Douglas K. Schneider, Jeffrey D. Lifson, Jacques Fellay, Steven G. Deeks, Jeffrey N. Martin, James J. Goedert, Steven M. Wolinsky, Nelson L. Michael, Gregory D. Kirk, Susan Buchbinder, David Haas, Thumbi Ndung'u, Philip Goulder, Peter Parham, Bruce D. Walker, Jonathan M. Carlson and Mary Carrington, Science (2018), 359:86-90.

Effect of population viral load on prospective HIV incidence in a hyperendemic rural African community.
Tanser F, Vandormael A, Cuadros D, Phillips AN, de Oliveira T, Tomita A, Barnighausen T, Pillay D, Science Translational Medicine (2017), 9:eaam8012.

Highlights of the second ISCB Student Council Symposium in Africa, 2017.
Rafael CN, Ashano E, Moosa Y, Shome S, DeBlasio D, F1000 Research (2017), 6(ISCB Comm J):2183 (doi: 10.12688/f1000research.13463.1).

HIV-1 drug resistance before initiation or re-initiation of first-line antiretroviral therapy in low-income and middle-income countries: a systematic review and meta-regression analysis.
Ravindra K Gupta, John Gregson, Neil Parkin, Hiwot Haile-Selassie, Amilcar Tanuri, Liliana Andrade Forero, Pontiano Kaleebu, Christine Watera, Avelin Aghokeng, Nicholus Mutenda, Janet Dzangare, San Hone, Zaw Zaw Hang, Judith Garcia, Zully Garcia, Paola Marchorro, Enrique Beteta, Amalia Giron, Raph Hamers, Seth Inzaule, Lisa M Frenkel, Michael H Chung, de Oliveira T, Deenan Pillay, Kogie Naidoo, Ayesha Kharsany, Ruthiran Kugathasan, Teresa Cutino, Gillian Hunt, Santiago Avila Rios, Meg Doherty, Michael R Jordan, Silvia Bertagnolio, Lancet Infectious Diseases (2017), :http://dx.doi.org/10.1016/S1473-3099(17)30702-8.

Universal test and treat and the HIV epidemic in rural South Africa: a phase 4, open-label, community cluster randomised trial.
Iwuji CC, Orne-Gliemann J, Larmarange J, Balestre E, Thiebaut R, Tanser F, Okesola N, Makowa T, Dreyer J, Herbst K, McGrath N, Barnighausen T, Boyer S, de Oliveira T, Rekacewicz C, Bazin B, Newell ML, Pillay D, Dabis F, for the ANRS 12249 TasP Study Group, Lancet HIV (2017), :http://dx.doi.org/10.1016/S2352-3018(17)30205-9.

All publications - Bioinformatics, genomics and drug resistance peer-reviewed papers on HIV, TB and other pathogens
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News News Section, printed & online media on HIV & TB drug resistance and bioinformatics (latest 5)

KRISP Papers

Science Editorial: Inhibiting natural killer cells in AIDS

KRISP Papers - 2018-01-04

The human leukocyte antigen (HLA) gene complex varies enormously among individuals and helps explain individual variation in immunity to infectious diseases. Ramsuran et al. (Science 2018) examined data from almost 10,000 HIV infections.


Why KRISP?

Why KRISP? KRISP challenges the status quo to create a scientific environment in South Africa that drives innovations & reverses the brain drain.

Why KRISP? - 2017-12-31

The Technology Innovation Agency (TIA) and UKZN have signed an agreement for the establishment of KRISP - the KwaZulu-Natal Research and Innovation Sequencing Platform.


KRISP Papers

Science TM Editorial: Status is not everything

KRISP Papers - 2017-12-15

Many parameters are examined to try to understand HIV transmission in endemic areas. Tanser et al. (Science TM 2017) use longitudinal population-based data from rural South Africa to show that population viral load indices incorporating geographical location and local HIV prevalence can be used to infer HIV transmission potential.


Scientists develop new prediction methods for HIV infection rates

- 2017-12-14

The Mercury, 14 December 2017, KwaZulu-Natal-based medical research organisations have developed an improved method to accurately predict where the highest rate of new HIV infections will likely occur in a community. Press coverage of our KRISP paper by Tanser et al. (Science TM 2017)


KRISP News

Even with easy access to ARVs, only one in three HIV-positive people will seek them

KRISP News - 2017-12-05

By Katharine Child, 05 December 2017. SA's policy to reduce HIV infections is to do what the UN recommends, which is to get 90% of people tested, 90% of HIV-positive people taking antiretrovirals and 90% of those on treatment taking it properly so they are not infectious. Press coverage of our KRISP paper Iwuji et al. (Lancet HIV 2017).


All news...
Blogs on bioinformatics, HIV & TB drug resistance, treatment, community engagement and bioinformatics in Africa Twitter

Bioinformaticians are pioneering the future of science

Author: Yumna Moosa - 2017-07-28


Meeting of the Swiss, Swedes and South Africans minds

Author: Nicolette Crozier, Benjamin Chimukangara, Veron Ramsuran - 2017-07-25


Megan Druce: from Cum Laude MSc to a Scholarship for a PhD in Germany...

Author: Megan Druce - 2016-04-18


Sthembiso Msweli: from Hlabisa to MSc and Further Promoted to Laboratory Manager...

Author: Sthembiso Msweli - 2016-04-17


Experience of 3 UKZN/Africa Centre students at the 7-week national bioinformatics workshop 2015

Author: Megan Druce, Zandile Sibisi & Sthembiso Msweli - 2015-04-23


15 minutes, All blogs...

Open access reports on HIV & TB drug resistance and bioinformatics in Africa HIV & TB Drug Resistance Clinical Cases Tutorial

SATuRN Collaborates on a Successful Molecular Diagnostics in HIV/AIDS and Tuberculosis in Zimbabwe, 6-9 Aug 2013

SATuRN 2013 report, date: 2013-08-21

Justen Manasa

SATuRN and Khethimpilo HIV Drug Resistance and Clinical Management Workshop Report, Durban, 11-12 July 2013

SATuRN 2013 report, date: 2013-08-01

Dean Solomon and Tulio de Oliveira

Major data analysis determines the trends of HIV-1 drug resistance mutations in South Africa.

SATuRN report 2013, date: 2013-07-01

Tulio de Oliveira

Transferring knowledge and skills to frontline medical personnel fighting the HIV & TB epidemics in rural South Africa

SATuRN 2013 report, date: 2013-03-16

Tulio de Oliveira, Justen Manasa, Richard Lessells

Bioafrica.net & SATuRN webpages received 186,746 visits in the past 12 months!

SATuRN 2013 report, date: 2013-02-26

Tulio de Oliveira

Clinical Case Study: The Diagnosis and Management of First-line Antiretroviral Treatment Failure

SATuRN 2012 report, date: 2013-01-16

Theresa Rossouw, Tulio de Oliveira & Richard Lessells

2nd Nurses and Health Care Workers Drug Resistance Training for the scale-up of resistance testing in the Free State Province, South Africa

SATuRN 2012 report, date: 2012-07-10

Dominique Goedhals & Cloete van Vuuren

SATuRN output, 15 minutes, All reports...

SATuRN output, 15 minutes, All cases...


Page design updated by Tulio de Oliveira, 2011