Introduction: Southern African Treatment and Resistance Network (SATuRN)

SATuRN currently includes 24 research partners in southern Africa that support our initiatives. We have collated over 7,000 resistance genotypes linked to treatment and clinical information and host two of the best HIV drug resistance databases in the world (The Stanford HIV Drug Resistance Database and RegaDB Clinical Management and Drug resistance Database). To advance access to drug resistance testing to patients, providers and programs, we have been working with a network of academics laboratories to develop and implement a cheaper resistance genotype test. We have also delivered training in drug resistance testing and management to over 2,000 physician and nurses in southern Africa...

SATuRN Newsletters:

SATuRN newsletters:

Num 2 V.3 (Apr-Jul 2014)

Num 1 V.3 (Jan-Mar 2014)

Num 4 V.2 (Oct-Dec 2013)

Num 3 V.2 (Jul-Sep 2013)


SATuRN Mission/Vision

SATuRN Executive Summary

Who We Are: SATuRN Management, Participant Scientists, International Advisory Board, Funders

Information for Collaborators:

Manual of Operations (MoO) - reference to SATuRN organization, functions and access of data

Memorandum of Understanding (MoU) - deposit of data in SATuRN drug resistance databases (MSWord format)

Contributors Guidelines - website, newsletters and annual reports

Public Resources: HIV & TB Book and Online Databases

HIV & TB Drug Resistance and Clinical Management Casebook - Open access

SATuRN Stanford HIV Drug Resistance Database (HIVDB) -  Public Drug Resistance Databases in Southern Africa (de Oliveira et al. Nature 2010, 464:673)

SATuRN RegaDB Clinical Management Database - A Collaborative Clinical HIV Drug Resistance Database in Southern Africa

Training and Capacity Building Workshops

AIDS Workshop on Advanced Clinical Care and SATuRN 9th HIV & TB Drug Resistance Workshop, Elangeni Sun Hotel, Durban South Africa, 9th to 10th October 2014.

19th International Bioinformatics Workshop on Virus Evolution and Molecular Epidemiology, National Institute for Infectious Diseases L Spallanzani, Rome, Italy, September 7-12, 2014

Open access pdf Publications (latest 5)

Renewing Felsenstein's phylogenetic bootstrap in the era of big data.
Lemoine F, Domelevo Entfellner JB, Wilkinson E, Correia D, Davila Felipe M, de Oliveira T, Gascuel O, Nature (2018), :doi:10.1038/s41586-018-0043-0.

Ethical issues associated with HIV phylogenetics in HIV transmission dynamics research: A review of the literature using the Emanuel Framework.
Mutenherwa F, Wassenaar DR, de Oliveira T, Developing World Bioethics (2018),

Spatial clustering of drug-resistant tuberculosis in Hlabisa subdistrict, KwaZulu-Natal, 2011-2015.
Smith CM, Lessells R, Grant AD, Herbst K, Tanser F, Int J Tuberc Lung Dis. (2018), 1;22(3):287-293. doi: 10.5588/ijtld.17.0457:.

Effect of genetic variation in UGT1A and ABCB1 on moxifloxacin pharmacokinetics in South African patients with tuberculosis.
Naidoo A, Ramsuran V, Chirehwa M, Denti P, McIlleron H, Naidoo K, Yende-Zuma N, Singh R, Ngcapu S, Chaudhry M, Pepper MS, Padayatchi N, Pharmacogenomics (2018), 19(1):17-29. doi: 10.2217/pgs-2017-0144:.

Case report: mechanisms of HIV elite control in two African women.
Moosa Y, Tanko RF, Ramsuran V, Singh R, Madzivhandila M, Yende-Zuma N, Abrahams MR, Selhorst P, Gounder K, Moore PL, Williamson C, Abdool Karim SS, Garrett NJ, Burgers WA, BMC Infect Dis (2018), 18(1):54. doi: 10.1186/s12879-018-2961-8:.

All publications - Bioinformatics, genomics and drug resistance peer-reviewed papers on HIV, TB and other pathogens
News News Section, printed & online media on HIV & TB drug resistance and bioinformatics (latest 5)


KRISP is reversing brain drain in Africa and achieving scientific excellence!

KRISP News - 2018-04-19

KRISP challenges the status quo to create a scientific environment in (South) Africa that delivers high level science, creates innovations and reverses the brain drain. This vision is starting to pay off, and we are happy to say that in just two years, we published ten manuscripts in Nature, Science and Lancet journals!

KRISP Papers

Nature paper: Renewing Felsenstein's phylogenetic bootstrap in the era of big data

KRISP Papers - 2018-04-18

KRISP Nature paper with Pasteur Institute on a new phylogenetic method to analyse large HIV and mammalian DNA sequence datasets!


Thought Leadership Workshop on Biomedical Innovation and Entrepreneurship - 10 April 2018, Pretoria, South Africa

KRISP & TIA News - 2018-04-10

The Department of Science and Technology (DST) funded Technology Innovation Agency (TIA) in collaboration with KRISP invites academics, government, clinicians, investors, law-makers, entrepreneurs and industrialists to an intellectually engaging exchange of ideas on the establishment of an innovative bio-incubation system. 10 April 2018, Pretoria, South Africa.


Laboratory-free virology research: Computational approaches for evolutionary hypothesis testing

KRISP Talks - 2018-04-09

KRISP Talks by Prof. Darren P Martin, IDMM, University of Cape Town (UCT), 9 April 2018 (12:00 - 13:00), K-RITH building, Nelson R Mandela School of Medicine, UKZN, Durban, South Africa. All welcome!

KRISP Newsletter

KRISP Newsletter - March 2018: Partnership with TIA, DST and SAMRC on a Thought Leadership Workshop in Pretoria, News, Publications and Collaborators

KRISP Newsletter - 2018-04-05

In our third issue of 2018, we would like to bring attention to a partnership with TIA, DST and SAMRC to deliver a Thought Leadership Workshop on Bio-Innovation. We also highlight some of our publications, collaborators and capacity building workshops

All news...
Blogs on bioinformatics, HIV & TB drug resistance, treatment, community engagement and bioinformatics in Africa Twitter

Bioinformaticians are pioneering the future of science

Author: Yumna Moosa - 2017-07-28

Meeting of the Swiss, Swedes and South Africans minds

Author: Nicolette Crozier, Benjamin Chimukangara, Veron Ramsuran - 2017-07-25

Megan Druce: from Cum Laude MSc to a Scholarship for a PhD in Germany...

Author: Megan Druce - 2016-04-18

Sthembiso Msweli: from Hlabisa to MSc and Further Promoted to Laboratory Manager...

Author: Sthembiso Msweli - 2016-04-17

Experience of 3 UKZN/Africa Centre students at the 7-week national bioinformatics workshop 2015

Author: Megan Druce, Zandile Sibisi & Sthembiso Msweli - 2015-04-23

15 minutes, All blogs...

Open access reports on HIV & TB drug resistance and bioinformatics in Africa HIV & TB Drug Resistance Clinical Cases Tutorial

SATuRN Collaborates on a Successful Molecular Diagnostics in HIV/AIDS and Tuberculosis in Zimbabwe, 6-9 Aug 2013

SATuRN 2013 report, date: 2013-08-21

Justen Manasa

SATuRN and Khethimpilo HIV Drug Resistance and Clinical Management Workshop Report, Durban, 11-12 July 2013

SATuRN 2013 report, date: 2013-08-01

Dean Solomon and Tulio de Oliveira

Major data analysis determines the trends of HIV-1 drug resistance mutations in South Africa.

SATuRN report 2013, date: 2013-07-01

Tulio de Oliveira

Transferring knowledge and skills to frontline medical personnel fighting the HIV & TB epidemics in rural South Africa

SATuRN 2013 report, date: 2013-03-16

Tulio de Oliveira, Justen Manasa, Richard Lessells & SATuRN webpages received 186,746 visits in the past 12 months!

SATuRN 2013 report, date: 2013-02-26

Tulio de Oliveira

Clinical Case Study: The Diagnosis and Management of First-line Antiretroviral Treatment Failure

SATuRN 2012 report, date: 2013-01-16

Theresa Rossouw, Tulio de Oliveira & Richard Lessells

2nd Nurses and Health Care Workers Drug Resistance Training for the scale-up of resistance testing in the Free State Province, South Africa

SATuRN 2012 report, date: 2012-07-10

Dominique Goedhals & Cloete van Vuuren

SATuRN output, 15 minutes, All reports...

SATuRN output, 15 minutes, All cases...

Page design updated by Prof. Tulio de Oliveira, 2011